New animal models of progressive neurodegeneration: tools for identifying targets in predictive diagnostics and presymptomatic treatment
Identifieur interne : 001A09 ( Main/Exploration ); précédent : 001A08; suivant : 001A10New animal models of progressive neurodegeneration: tools for identifying targets in predictive diagnostics and presymptomatic treatment
Auteurs : R. Andrew Tasker [Canada] ; Amber L. Adams-Marriott [Canada] ; Christopher A. ShawSource :
- The EPMA Journal [ 1878-5077 ] ; 2010.
Abstract
Mental and neurological disorders are increasingly prevalent and constitute a major societal and economic burden worldwide. Many of these diseases and disorders are characterized by progressive deterioration over time, that ultimately results in identifiable symptoms that in turn dictate therapy. Disease-specific symptoms, however, often occur late in the degenerative process. A better understanding of presymptomatic events could allow for the development of new diagnostics and earlier interventions that could slow or stop the disease process. Such studies of progressive neurodegeneration require the use of animal models that are characterized by delayed or slowly developing disease phenotype(s). This brief review describes several examples of such animal models that have recently been developed with relevance to various neurological diseases and disorders, and delineates the potential of such models to aid in predictive diagnosis, early intervention and disease prevention.
Url:
DOI: 10.1007/s13167-010-0019-0
PubMed: 23199060
PubMed Central: 3405326
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">New animal models of progressive neurodegeneration: tools for identifying targets in predictive diagnostics and presymptomatic treatment</title><author><name sortKey="Tasker, R Andrew" sort="Tasker, R Andrew" uniqKey="Tasker R" first="R. Andrew" last="Tasker">R. Andrew Tasker</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Biomedical Sciences, University of Prince Edward Island, 550 University Avenue, Charlottetown, PEI, Canada C1A4P3</nlm:aff><country>Canada</country><wicri:regionArea>Department of Biomedical Sciences, University of Prince Edward Island, 550 University Avenue, Charlottetown, PEI</wicri:regionArea><wicri:noRegion>PEI</wicri:noRegion></affiliation></author><author><name sortKey="Adams Marriott, Amber L" sort="Adams Marriott, Amber L" uniqKey="Adams Marriott A" first="Amber L." last="Adams-Marriott">Amber L. Adams-Marriott</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Biomedical Sciences, University of Prince Edward Island, 550 University Avenue, Charlottetown, PEI, Canada C1A4P3</nlm:aff><country>Canada</country><wicri:regionArea>Department of Biomedical Sciences, University of Prince Edward Island, 550 University Avenue, Charlottetown, PEI</wicri:regionArea><wicri:noRegion>PEI</wicri:noRegion></affiliation></author><author><name sortKey="Shaw, Christopher A" sort="Shaw, Christopher A" uniqKey="Shaw C" first="Christopher A." last="Shaw">Christopher A. 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Andrew" last="Tasker">R. Andrew Tasker</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Biomedical Sciences, University of Prince Edward Island, 550 University Avenue, Charlottetown, PEI, Canada C1A4P3</nlm:aff><country>Canada</country><wicri:regionArea>Department of Biomedical Sciences, University of Prince Edward Island, 550 University Avenue, Charlottetown, PEI</wicri:regionArea><wicri:noRegion>PEI</wicri:noRegion></affiliation></author><author><name sortKey="Adams Marriott, Amber L" sort="Adams Marriott, Amber L" uniqKey="Adams Marriott A" first="Amber L." last="Adams-Marriott">Amber L. Adams-Marriott</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Biomedical Sciences, University of Prince Edward Island, 550 University Avenue, Charlottetown, PEI, Canada C1A4P3</nlm:aff><country>Canada</country><wicri:regionArea>Department of Biomedical Sciences, University of Prince Edward Island, 550 University Avenue, Charlottetown, PEI</wicri:regionArea><wicri:noRegion>PEI</wicri:noRegion></affiliation></author><author><name sortKey="Shaw, Christopher A" sort="Shaw, Christopher A" uniqKey="Shaw C" first="Christopher A." last="Shaw">Christopher A. Shaw</name><affiliation><nlm:aff id="Aff2">Department of Opthalmology, University of British Columbia, Vancouver, BC Canada</nlm:aff><wicri:noCountry code="subfield">BC Canada</wicri:noCountry></affiliation></author></analytic><series><title level="j">The EPMA Journal</title><idno type="ISSN">1878-5077</idno><idno type="eISSN">1878-5085</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Mental and neurological disorders are increasingly prevalent and constitute a major societal and economic burden worldwide. Many of these diseases and disorders are characterized by progressive deterioration over time, that ultimately results in identifiable symptoms that in turn dictate therapy. Disease-specific symptoms, however, often occur late in the degenerative process. A better understanding of presymptomatic events could allow for the development of new diagnostics and earlier interventions that could slow or stop the disease process. Such studies of progressive neurodegeneration require the use of animal models that are characterized by delayed or slowly developing disease phenotype(s). This brief review describes several examples of such animal models that have recently been developed with relevance to various neurological diseases and disorders, and delineates the potential of such models to aid in predictive diagnosis, early intervention and disease prevention.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Schulz, Jb" uniqKey="Schulz J">JB Schulz</name></author><author><name sortKey="Falkenburger, Bh" uniqKey="Falkenburger B">BH Falkenburger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shaw, Ca" uniqKey="Shaw C">CA Shaw</name></author><author><name sortKey="Hoglinger, Gu" uniqKey="Hoglinger G">GU Hoglinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vorhees, Cv" uniqKey="Vorhees C">CV Vorhees</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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E">E Petroske</name></author><author><name sortKey="Merdith, Ge" uniqKey="Merdith G">GE Merdith</name></author><author><name sortKey="Callen, S" uniqKey="Callen S">S Callen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alvarez Fischer, D" uniqKey="Alvarez Fischer D">D Alvarez-Fischer</name></author><author><name sortKey="Guerreiro, S" uniqKey="Guerreiro S">S Guerreiro</name></author><author><name sortKey="Hunot, S" uniqKey="Hunot S">S Hunot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schintu, N" uniqKey="Schintu N">N Schintu</name></author><author><name sortKey="Frau, L" uniqKey="Frau L">L Frau</name></author><author><name sortKey="Ibba, M" uniqKey="Ibba M">M Ibba</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Shaw, Christopher A" sort="Shaw, Christopher A" uniqKey="Shaw C" first="Christopher 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Shaw</name></noCountry><country name="Canada"><noRegion><name sortKey="Tasker, R Andrew" sort="Tasker, R Andrew" uniqKey="Tasker R" first="R. Andrew" last="Tasker">R. Andrew Tasker</name></noRegion><name sortKey="Adams Marriott, Amber L" sort="Adams Marriott, Amber L" uniqKey="Adams Marriott A" first="Amber L." last="Adams-Marriott">Amber L. Adams-Marriott</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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